|
The UCLA Immunogenetics Center's research efforts are focused on identifying the mechanisms underlying organ and tissue transplant rejection and developing diagnostic markers to identify patients at risk of rejection. The laboratory performs various tests including cytokine gene expression, anti-HLA antibody production and T lymphocyte activation to assess the immune status of the patient and response to immunotherapy.
UCLA Immunogenetics Center performs class I and class II gene polymorphism testing for investigators studying the association between HLA and disease.
The UCLA Immunogenetics Center offers a variety of statistical modeling services to study factors influencing transplant outcome, assess the role of HLA genes in the development of disease, and characterize genetic and immune markers of rejection.
The UCLA Immunogenetics Center participates in studies aimed at understanding how polymorphisms in HLA molecules determine the nature of the antigenic peptides presented by HLA molecules and the application of this knowledge to vaccine development. The laboratory performs allele level typing of HLA-A, -B, -C, DRB and DQB loci to support vaccine development and clinical trials.
The UCLA Immunogenetics Center maintains a biological specimen repository for clinical and research use. Services include whole blood, lymphocyte and serum storage, EBV transformation, and nucleic acid isolation and storage.
|
